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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 390181Generated: October 30, 2026

2-Methylspiro[isoindoline-3,4'-piperidine]-1-one → 2-Methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one

https://huagongshe.com/reaction/390181

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methylspiro[isoindoline-3,4'-piperidine]-1-oneHCID 12112518—
Reactant2-(Trifluoromethyl)benzenepropanoic acidHCID 15284809—
Product2-Methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-oneHCID 58295689—

Reaction Steps

The title compound was prepared following a procedure analogous to that described in Example 1 using 3-(2-(trifluoromethyl)phenyl)propanoic acid and 2-methylspiro[isoindoline-1,4′-piperidin]-3-one. LC-MS Method 1 tR=1.65, min, m/z=417, 415.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08383629B2
Source datasetuspto-grants-2013_02
ORD IDord-65e20ce5741449bfa5870697c8e63531
Source noteuspto-grants-2013_02