2-(Trifluoromethyl)benzenepropanoic acid → 7-Chloro-2-methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one

HRID 390184Notes

Reaction equation

HRID 390184 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([OH:13])=O.[Cl:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:30]=1[C:24]1([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[N:23]([CH3:31])[C:22]2=[O:32]>>[Cl:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:30]=1[C:24]1([CH2:25][CH2:26][N:27]([C:11](=[O:13])[CH2:10][CH2:9][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:2]([F:1])([F:15])[F:14])[CH2:28][CH2:29]1)[N:23]([CH3:31])[C:22]2=[O:32]

Participants

3

Reactant 2

HCID 152848092-(Trifluoromethyl)benzenepropanoic acidHCID 582957967-Chloro-2-methylspiro[isoindoline-1,4'-piperidin]-3-one

Product 1

HCID 582956887-Chloro-2-methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one

Procedure

The title compound was prepared following a procedure analogous to that described in Example 1 using 3-(2-(trifluoromethyl)phenyl)propanoic acid and 7-chloro-2-methylspiro[isoindoline-1,4′-piperidin]-3-one. LC-MS Method 1 tR=1.77, min, m/z=453, 451

Sources & evidence

ORD record
ord-7c49d4a9f15543d7b803b416fa0cf866
Source dataset
uspto-grants-2013_02
Patent number
US08383629B2

Reaction notes

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