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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 390184Generated: October 29, 2026

2-(Trifluoromethyl)benzenepropanoic acid → 7-Chloro-2-methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one

https://huagongshe.com/reaction/390184

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethyl)benzenepropanoic acidHCID 15284809—
Reactant7-Chloro-2-methylspiro[isoindoline-1,4'-piperidin]-3-oneHCID 58295796—
Product7-Chloro-2-methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-oneHCID 58295688—

Reaction Steps

The title compound was prepared following a procedure analogous to that described in Example 1 using 3-(2-(trifluoromethyl)phenyl)propanoic acid and 7-chloro-2-methylspiro[isoindoline-1,4′-piperidin]-3-one. LC-MS Method 1 tR=1.77, min, m/z=453, 451

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08383629B2
Source datasetuspto-grants-2013_02
ORD IDord-7c49d4a9f15543d7b803b416fa0cf866
Source noteuspto-grants-2013_02