2-Ethoxybenzyl isocyanate → Ethyl 2-(7-bromo-1'-(2-ethoxybenzylcarbamoyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetate

HRID 390192Notes

Reaction equation

HRID 390192 reaction equation
[CH2:1]([O:3][C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[CH2:6][N:7]=[C:8]=[O:9])[CH3:2].[Br:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:28]=1[C:22]1([CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[CH2:21][CH:20]2[CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31]>>[Br:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:28]=1[C:22]1([CH2:23][CH2:24][N:25]([C:8](=[O:9])[NH:7][CH2:6][C:5]3[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=3[O:3][CH2:1][CH3:2])[CH2:26][CH2:27]1)[CH2:21][CH:20]2[CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31]

Participants

3

Reactant 2

HCID 46383562-Ethoxybenzyl isocyanateHCID 58137336Ethyl 2-(7-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetate

Product 1

HCID 44227076Ethyl 2-(7-bromo-1'-(2-ethoxybenzylcarbamoyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetate

Procedure

The title compound was prepared following a procedure analogous to that described in Example 19 using 2-ethoxybenzyl isocyanate and ethyl 2-(7-bromo-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetate. 1H NMR (CDCl3) [selected resonances] 1.28 (t, 3H), 1.44 (t, 3H), 4.11 (q, 2H), 4.19 (q, 2H), 4.45 (s, 2H).

Sources & evidence

ORD record
ord-ad3763bfd23d415692bef5560bc14b7f
Source dataset
uspto-grants-2013_02
Patent number
US08383629B2

Reaction notes

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