HCID 58625150, compound → 3-Propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-ylamine

HRID 390223Notes

Reaction equation

HRID 390223 reaction equation
C(OC(=O)[NH:7][C:8]1[N:17]([CH2:18][CH2:19][CH3:20])[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH:29][CH2:30][C:31]4[C:36]([CH3:37])=[CH:35][C:34]([CH3:38])=[CH:33][C:32]=4[CH3:39])[CH:23]=3)[CH:14]=2)[N:9]=1)(C)(C)C>FC(F)(F)C(O)=O.C(Cl)Cl>[CH2:18]([N:17]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH:29][CH2:30][C:31]4[C:36]([CH3:37])=[CH:35][C:34]([CH3:38])=[CH:33][C:32]=4[CH3:39])[CH:23]=3)[CH:14]=2)[N:9]=[C:8]1[NH2:7])[CH2:19][CH3:20]

Participants

4

Reactant 1

HCID 58625150HCID 58625150, compound

Product 1

HCID 586250493-Propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-ylamine

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of (3-propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-yl)-carbamic acid tert-butyl ester (0.00041 mol) in trifluoroacetic acid (1 mL) and DCM (10 mL) was stirred overnight at room temperature and the solvent was evaporated. The obtained residue was decomposed in diisopropyl ether/CH3CN, then the desired product was filtered off and dried to yield the title compound as a solid.

Workup

  1. customthe solvent was evaporated
  2. filtrationthe desired product was filtered off
  3. customdried

Sources & evidence

ORD record
ord-04c0888568b34353b2bed9dfba233689
Source dataset
uspto-grants-2013_02
Patent number
US08383637B2

Reaction notes

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