Cyanogen Bromide → HCID 58625098, compound

HRID 390233Notes

Reaction equation

HRID 390233 reaction equation
[N:1]#[C:2]Br.[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][CH2:18][NH:19][S:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)(=[O:22])=[O:21])=[CH:7][C:6]=1[CH2:29][NH:30][CH2:31][CH2:32][CH3:33]>C(O)C>[NH2:1][C:2]1[N:30]([CH2:31][CH2:32][CH3:33])[CH2:29][C:6]2[C:5](=[CH:10][CH:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH2:17][CH2:18][NH:19][S:20]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)(=[O:22])=[O:21])[CH:7]=2)[N:4]=1

Participants

4

Reactant 2

HCID 10476Cyanogen BromideHCID 58625144HCID 58625144, compound

Product 1

HCID 58625098HCID 58625098, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Cyanogen bromide (0.00034 mol) was added to a mixture of N-[2-(4′-amino-3′-propylaminomethyl-biphenyl-2-yl)-ethyl]-benzenesulfonamide (0.00031 mol) in ethanol (1 mL) in a Fast-tube, and then the reaction mixture was stirred overnight at room temperature. The solvent was evaporated and the residue was purified by high-performance liquid chromatography. The purest product fractions were collected and the solvent was evaporated to yield the title compound as a residue.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by high-performance liquid chromatography
  3. customThe purest product fractions were collected
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-4ed908823dd440dab22600e1c982701b
Source dataset
uspto-grants-2013_02
Patent number
US08383637B2

Reaction notes

Loading…