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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 390241Generated: October 31, 2026

HCID 58625122, compound → 3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

https://huagongshe.com/reaction/390241

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 58625122HCID 58625122—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
Product3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamineHCID 58625123—

Reaction Steps

A mixture of {3-propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-yl}-carbamic acid tert-butyl ester (0.0001 mol) in 10% TFA in DCM (6 mL) was stirred in a reaction vial for 1 hour at room temperature and then the solvent was evaporated. The obtained residue was crystallized from CH3CN, and then the desired product was filtered off, washed with diisopropyl ether and dried under vacuum to yield the title compound as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08383637B2
Source datasetuspto-grants-2013_02
ORD IDord-0630ee75e71c4de695e0af9f8088003f
Source noteuspto-grants-2013_02