HCID 58625122, compound → 3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

HRID 390241Notes

Reaction equation

HRID 390241 reaction equation
C(OC(=O)[NH:7][C:8]1[N:17]([CH2:18][CH2:19][CH3:20])[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][CH2:29][C:30]4[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][C:31]=4[CH3:38])[CH:23]=3)[CH:14]=2)[N:9]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:18]([N:17]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][CH2:29][C:30]4[C:31]([CH3:38])=[CH:32][C:33]([CH3:37])=[CH:34][C:35]=4[CH3:36])[CH:23]=3)[CH:14]=2)[N:9]=[C:8]1[NH2:7])[CH2:19][CH3:20]

Participants

4

Reactant 1

HCID 58625122HCID 58625122, compound

Product 1

HCID 586251233-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of {3-propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-yl}-carbamic acid tert-butyl ester (0.0001 mol) in 10% TFA in DCM (6 mL) was stirred in a reaction vial for 1 hour at room temperature and then the solvent was evaporated. The obtained residue was crystallized from CH3CN, and then the desired product was filtered off, washed with diisopropyl ether and dried under vacuum to yield the title compound as a solid.

Workup

  1. customthe solvent was evaporated
  2. customThe obtained residue was crystallized from CH3CN
  3. filtrationthe desired product was filtered off
  4. washwashed with diisopropyl ether
  5. customdried under vacuum

Sources & evidence

ORD record
ord-0630ee75e71c4de695e0af9f8088003f
Source dataset
uspto-grants-2013_02
Patent number
US08383637B2

Reaction notes

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