Thiophene → HCID 58625102, compound

HRID 390257Notes

Reaction equation

HRID 390257 reaction equation
[CH2:1]([O:8][C:9](=[O:38])[N:10]([CH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1)[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[C:20]([CH2:27][NH:28][CH2:29][CH2:30][CH3:31])[CH:19]=2)[CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S1C=CC=C1>CO.[Pt]>[CH2:1]([O:8][C:9](=[O:38])[N:10]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[C:20]([CH2:27][NH:28][CH2:29][CH2:30][CH3:31])[CH:19]=2)[CH:12]=1)[CH:32]1[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 8030ThiopheneHCID 58625080HCID 58625080, compound

Product 1

HCID 58625102HCID 58625102, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture of cyclohexyl-[3-(4-nitro-3-propylaminomethyl-phenoxy)-phenyl]-carbamic acid benzyl ester (0.00181 mol) in methanol (50 mL) was hydrogenated with 5% Pt/C (0.5 g) as a catalyst in the presence of thiophene solution (1 mL). After uptake of H2 (3 equiv), the catalyst was filtered off and the filtrate was evaporated to yield the title compound as a residue which was used in subsequent reactions without further purification.

Workup

  1. filtrationAfter uptake of H2 (3 equiv), the catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-61dfb71e8ad04cfcac62a756c5b658a1
Source dataset
uspto-grants-2013_02
Patent number
US08383637B2

Reaction notes

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