HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 390279Generated: November 1, 2026
Water → 3-(3-Dimethoxymethyl-4-nitro-phenylsulfanyl)-phenylamine
https://huagongshe.com/reaction/390279
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Aminothiophenol | HCID 31577 | — |
| Reactant | 4-Chloro-2-(dimethoxymethyl)-1-nitrobenzene | HCID 3570093 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 3-(3-Dimethoxymethyl-4-nitro-phenylsulfanyl)-phenylamine | HCID 58625054 | — |
Reaction Steps
K2CO3 (0.085 mol) was added to a mixture of 3-aminobenzenethiol (0.075 mol) in DMA (150 mL). Then 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.050 mol) was added and the reaction mixture was stirred for 2 hours at 80° C. H2O was added and the mixture was extracted with diisopropyl ether. The crude product was purified by column chromatography (eluent: 70:30 CH2Cl2/hexane up to 99:1 CH2Cl2:CH3OH). The product fractions were collected, and the solvent was evaporated to yield the title compound as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08383637B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-7454321767954ad28e8064ce8b204d95 |
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| Source note | uspto-grants-2013_02 |
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