反应详情

温度

80 °C

K2CO3 (0.085 mol) was added to a mixture of 3-aminobenzenethiol (0.075 mol) in DMA (150 mL). Then 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.050 mol) was added and the reaction mixture was stirred for 2 hours at 80° C. H2O was added and the mixture was extracted with diisopropyl ether. The crude product was purified by column chromatography (eluent: 70:30 CH2Cl2/hexane up to 99:1 CH2Cl2:CH3OH). The product fractions were collected, and the solvent was evaporated to yield the title compound as a residue.

1. extractionthe mixture was extracted with diisopropyl ether
2. customThe crude product was purified by column chromatography (eluent
3. customThe product fractions were collected
4. customthe solvent was evaporated