反应详情

温度

80 °C

To a solution of 6-(1-benzyl-pyrrolidin-3-yloxy)-2-methoxy-3-nitro-pyridine (0.38 g, 1.15 mmol) in acetic acid (4 ml) at 80° C. was added iron (0.32 g, 5.77 mmol) slowly in portions. The exothermic reaction was stirred for 3 h at 80° C. After evaporation of the solvent under reduced pressure the solid residue was dissolved in 1N NaOH, which was extracted 6 times with dichloromethane. The combined organic layers were dried over MgSO4, filtered and the solvent evaporated to obtain 240 mg (68.9%) of the title compound.

1. customThe exothermic reaction
2. customAfter evaporation of the solvent under reduced pressure the solid residue
3. dissolutionwas dissolved in 1N NaOH
4. extractionwhich was extracted 6 times with dichloromethane
5. dry with materialThe combined organic layers were dried over MgSO4
6. filtrationfiltered
7. customthe solvent evaporated