HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-(6-Methoxy-5-nitro-pyridin-2-yloxymethyl)-pyrrolidine-1-carboxylic Acid Tert-Butyl Ester → (S)-2-(5-Amino-6-methoxy-pyridin-2-yloxymethyl)-pyrrolidine-1-carboxylic Acid Tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-(6-Methoxy-5-nitro-pyridin-2-yloxymethyl)-pyrrolidine-1-carboxylic Acid Tert-Butyl Ester | HCID 66883424 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-2-(5-Amino-6-methoxy-pyridin-2-yloxymethyl)-pyrrolidine-1-carboxylic Acid Tert-Butyl Ester | HCID 66883332 | 96.6% |
Reaction Steps
A solution of (S)-2-(6-methoxy-5-nitro-pyridin-2-yloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.11 g, 0.32 mmol) in methanol (11 ml) was hydrogenated using the ThalesNano H-Cube® hydrogenation reactor employing a 10% palladium on charcoal catalyst cartridge. After concentration of the solution under reduced pressure 0.10 g (92.6%) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383641B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-e397307cfb0c47918e493be35fc99d26 |
| Source note | uspto-grants-2013_02 |