2-Fluoropyridine → 4-(4-Methylpyridin-2-yl)piperidine-4-carbonitrile

HRID 390321Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([C:13]#[N:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.F[C:16]1C=CC=CN=1>>[CH3:16][C:4]1[CH:5]=[CH:6][N:1]=[C:2]([C:7]2([C:13]#[N:14])[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[CH:3]=1

Participants

Reactant 2

HCID 97462-Fluoropyridine

HCID 533632714-(Pyridin-2-yl)piperidine-4-carbonitrile

Product 1

HCID 533632764-(4-Methylpyridin-2-yl)piperidine-4-carbonitrile

Procedure

4-(4-methylpyridin-2-yl)piperidine-4-carbonitrile was prepared by the procedure described for the synthesis of 4-pyridin-2-ylpiperidine-4-carbonitrile in Example 1, substituting 2-fluoro-4-methylpyridine for 2-fluoropyridine.

Sources & evidence

ORD record: ord-094bebafd97c40b5be962f26408c29e2
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08383638B2

Reaction notes

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