反应详情

To a solution of piperidine-1,3,5-tricarboxylic acid 1-tert-butyl ester 3,5-dimethyl ester (6.8 g, 22.5 mmol) in MeOH/water (4:1, 120 mL) is added K2CO3 (9.4 g, 68 mmol). The reaction mixture is stirred at reflux overnight. The MeOH is evaporated and the residue is extracted with dicholoromethane and 1N aq. HCl. The organic phase is dried over Na2SO4, filtered and evaporated to give a light yellow solid. MS (LC-MS): 274 [M+H]+.

1. temperatureat reflux overnight
2. customThe MeOH is evaporated
3. extractionthe residue is extracted with dicholoromethane and 1N aq. HCl
4. dry with materialThe organic phase is dried over Na2SO4
5. filtrationfiltered
6. customevaporated
7. customto give a light yellow solid