反应详情

To a solution of tert-butyl spiro[indole-3,4′-piperidine]-1(2H)-carboxylate-3-{2-fluoro-4-[(4-methylbenzyl)oxy]phenyl}propanoic acid (0.12 g, 0.208 mmol) in methanol (5 mL), is added HCl in methanol (4 M, 5 mL) at 0° C. The reaction mixture is allowed to warm to room temperature and stirred for 1 hour. The reaction mixture is evaporated to dryness to give the title compound as a pale yellow solid (0.07 g, 64%). ESI/MS m/z 489.6 (M+H)+.

1. customThe reaction mixture is evaporated to dryness