反应详情

A mixture of 1 (30 mg, 0.067 mmol) and 10% Pd/C (20 mg) in methanol (10 mL) and THF (10 mL) was shaken in a hydrogenation apparatus under 55 psi pressure at room temperature for 1 h. The catalyst was removed by filtration and washed with methanol. The filtrate was concentrated to dryness. Filtration on silica gel afforded 24 mg (80%) of the target product 2: m/z=448 (M+H)+.

1. customThe catalyst was removed by filtration
2. washwashed with methanol
3. concentrationThe filtrate was concentrated to dryness
4. filtrationFiltration on silica gel