Cesium carbonate → HCID 58066681, compound

HRID 390416Notes

Reaction equation

HRID 390416 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]#[N:8])[CH:3]=[N:2]1.Br[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:13][C:12]=1[CH2:24][S:25][C:26]([CH3:29])([CH3:28])[CH3:27].C(=O)([O-])[O-].[Cs+].[Cs+]>CC#N>[C:26]([S:25][CH2:24][C:12]1[CH:13]=[C:14]([NH:17][C:18](=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20])[CH:15]=[CH:16][C:11]=1[CH2:10][N:1]1[CH:5]=[C:4]([CH2:6][C:7]#[N:8])[CH:3]=[N:2]1)([CH3:29])([CH3:28])[CH3:27]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 205427002-(1H-Pyrazol-4-yl)acetonitrileHCID 58066671HCID 58066671, compound

Product 1

HCID 58066681HCID 58066681, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

(1H-Pyrazol-4-yl)-acetonitrile (0.19 g, 1.77 mmol) and N-(4-bromomethyl-3-tert-butylsulfanylmethyl-phenyl)-2,2-dimethyl-propionamide (0.20 g, 0.55 mmol) were combined in MeCN. Cesium carbonate (0.95 g, 2.90 mmol) was added, and the reaction was stirred for 45 minutes at room temperature. The mixture was worked-up and purified by silica gel chromatography to give the title compound.

Workup

  1. custompurified by silica gel chromatography

Sources & evidence

ORD record
ord-5d951142a32340fa98a32ed337862b90
Source dataset
uspto-grants-2013_02
Patent number
US08383654B2

Reaction notes

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