Lithium Hydroxide → HCID 46208545, compound

HRID 390419Notes

Reaction equation

HRID 390419 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][C:6]1[CH:7]=[N:8][N:9]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:14][C:13]=2[CH2:25][S:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:10]=1)C.[OH-].[Li+]>CO.O>[C:27]([S:26][CH2:25][C:13]1[CH:14]=[C:15]([NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[CH:16]=[CH:17][C:12]=1[CH2:11][N:9]1[CH:10]=[C:6]([CH2:5][C:4]([OH:31])=[O:3])[CH:7]=[N:8]1)([CH3:30])([CH3:29])[CH3:28]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58066682HCID 58066682, compound

Product 1

HCID 46208545HCID 46208545, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

{1-[2-tert-Butylsulfanylmethyl-4-(2,2-dimethyl-propionylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester (0.038 g, 0.09 mmol) in MeOH and H2O was hydrolyzed with lithium hydroxide to give the title compound.

Sources & evidence

ORD record
ord-e31d85b6a0c549c596dfceb55e86430a
Source dataset
uspto-grants-2013_02
Patent number
US08383654B2

Reaction notes

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