Ammonia → HCID 69004301, compound

HRID 390450Notes

Reaction equation

HRID 390450 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6](Cl)=[N:7][OH:8])#[N:2].[C:13]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)#[CH:14].N>>[N:17]1[CH:18]=[CH:19][CH:20]=[C:15]([C:13]2[O:8][N:7]=[C:6]([C:5]3[CH:4]=[C:3]([CH:12]=[CH:11][CH:10]=3)[C:1]#[N:2])[CH:14]=2)[CH:16]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1860033-EthynylpyridineHCID 76221309HCID 76221309, compound

Product 1

HCID 69004301HCID 69004301, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 18B (91 mg, 0.5 mmol) and 3-ethynylpyridine (Aldrich, 52 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.64 (dd, J=7.5, 4.4 Hz, 1H), 7.80 (t, J=7.5 Hz, 1H), 7.89 (s, 1H), 8.04 (dt, J=7.7, 1.3 Hz, 1H), 8.21-8.34 (m, 2H), 8.38 (t, J=1.4 Hz, 1H), 8.74 (dd, J=4.8, 1.6 Hz, 1H), 9.13 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 248 (M+H)+.

Sources & evidence

ORD record
ord-4f1e0c2886f84f25939c8d5c84e4f8da
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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