Ammonia → HCID 44546354, compound

HRID 390472Notes

Reaction equation

HRID 390472 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=1)#[CH:13].N>>[F:1][C:2]1[CH:11]=[C:6]([C:7]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=3)[O:9][N:8]=2)[CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1366003-MethylphenylacetyleneHCID 866368465-Fluoro-N-hydroxynicotinimidoyl chloride

Product 1

HCID 44546354HCID 44546354, compound

Procedure

The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 1-ethynyl-3-methylbenzene (Aldrich, 58 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 2.44 (s, 3H), 7.29-7.38 (m, 2 H), 7.42 (t, J=7.6 Hz, 1H), 7.64-7.81 (m, 2H), 8.17 (ddd, J=9.4, 2.8, 1.7 Hz, 1H), 8.60 (d, J=2.7 Hz, 1H), 8.97 (t, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 255 (M+H)+.

Sources & evidence

ORD record
ord-cddee0c7d96b42bb8bc149893b94cb5a
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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