Ammonia → HCID 44546487, compound

HRID 390491Notes

Reaction equation

HRID 390491 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:5]=[N:6][CH:7]=[N:8][CH:9]=1.[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=1)#[CH:12].N>>[N:6]1[CH:5]=[C:4]([C:3]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]([CH3:19])[CH:16]=[CH:17][CH:18]=3)[O:1][N:2]=2)[CH:9]=[N:8][CH:7]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1366003-MethylphenylacetyleneHCID 86636847N-Hydroxypyrimidine-5-carbimidoyl chloride

Product 1

HCID 44546487HCID 44546487, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and 1-ethynyl-3-methylbenzene (Aldrich, 58 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 2.42 (s, 3H), 7.39 (d, J=7.8 Hz, 1H), 7.49 (t, J=7.8 Hz, 1H), 7.67-7.79 (m, 3H), 9.33 (s, 2 H), 9.35 (s, 1H) ppm; MS (DCI/NH3) m/z 238 (M+H)+.

Sources & evidence

ORD record
ord-b80b315afcb44caa987b5f543b266bf0
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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