Ammonia → HCID 44546541, compound

HRID 390492Notes

Reaction equation

HRID 390492 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[C:12]([C:14]1[CH:15]=[C:16]([C:22]#[N:23])[C:17](=[CH:20][CH:21]=1)[C:18]#[N:19])#[CH:13].N>>[F:1][C:2]1[CH:11]=[C:6]([C:7]2[CH:13]=[C:12]([C:14]3[CH:15]=[C:16]([C:22]#[N:23])[C:17](=[CH:20][CH:21]=3)[C:18]#[N:19])[O:9][N:8]=2)[CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 86140908HCID 86140908, compoundHCID 866368465-Fluoro-N-hydroxynicotinimidoyl chloride

Product 1

HCID 44546541HCID 44546541, compound

Procedure

The titled compound was prepared according to Method CB using the product of product of Example 28B (88 mg, 0.5 mmol) and product of Example 60A (76 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) 87.71 (s, 1H), 8.15 (d, J=8.8 Hz, 1H), 8.19 (ddd, J=9.2, 2.7, 1.7 Hz, 1H), 8.37 (dd, J=8.2, 2.7 Hz, 1H), 8.55 (d, J=1.4 Hz, 1H), 8.63 (d, J=2.7 Hz, 1H), 8.98 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 291 (M+H)+.

Sources & evidence

ORD record
ord-082510f21f2242649213fc5cdb68e0bb
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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