Ammonia → HCID 44546543, compound

HRID 390496Notes

Reaction equation

HRID 390496 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[F:12][CH:13]([F:23])[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[CH:22])[CH:16]=1.N>>[F:12][CH:13]([F:23])[O:14][C:15]1[CH:16]=[C:17]([C:21]2[O:9][N:8]=[C:7]([C:6]3[CH:5]=[N:4][CH:3]=[C:2]([F:1])[CH:11]=3)[CH:22]=2)[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 27784953-(Difluoromethoxy)phenylacetyleneHCID 866368465-Fluoro-N-hydroxynicotinimidoyl chloride

Product 1

HCID 44546543HCID 44546543, compound

Procedure

The titled compound was prepared according to Method CB using the product of product of Example 28B (88 mg, 0.5 mmol) and 1-(difluoromethoxy)-3-ethynylbenzene (Fluorochemicals, 84 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 6.95 (s, 1H), 7.31 (dd, J=8.3, 2.0 Hz, 1H), 7.47 (s, 1H), 7.59 (t, J=8.1 Hz, 1H), 7.70 (t, J=2.1 Hz, 1H), 7.77-7.83 (m, 1H), 8.18 (ddd, J=9.3, 2.8, 1.8 Hz, 1H), 8.61 (d, J=2.8 Hz, 1H), 8.98 (t, J=1.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 307 (M+H)+.

Sources & evidence

ORD record
ord-5ac3f0fff59943b2b93c7ac0f6795261
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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