HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(4-Chlorophenyl)-3-(5-chloropyridin-3-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Benzene, 1-chloro-4-ethynyl- | HCID 70118 | — |
| Reactant | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Product | 5-(4-Chlorophenyl)-3-(5-chloropyridin-3-yl)isoxazole | HCID 44545539 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 1-chloro-4-ethynylbenzene (Aldrich, 41 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ7.69 (dt, J=8.9, 2.6, 2.4 Hz, 2H), 7.82 (s, 1H), 7.93 (dt, J=8.9, 2.4, 2.2 Hz, 2H), 8.44 (t, J=2.2 Hz, 1H), 8.81 (d, J=2.4 Hz, 1H), 9.08 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 291 (M+H)+, 293 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-c18c93d68bd34ba1b37ecc1b3bb40ee2 |
| Source note | uspto-grants-2013_02 |