Ammonia → HCID 44545682, compound

HRID 390524Notes

Reaction equation

HRID 390524 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[N:8][CH:7]=[CH:6][N:5]=1.[C:11]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)#[CH:12].N>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:9]=[N:8][CH:7]=[CH:6][N:5]=3)[CH:12]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 5226271-Ethynyl-4-fluorobenzeneHCID 136395910N-Hydroxypyrazine-2-carbimidoyl chloride

Product 1

HCID 44545682HCID 44545682, compound

Procedure

The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and 1-ethynyl-4-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 5.70-5.81 (m, 2H), 5.85 (s, 1 H), 6.35-6.55 (m, 2H), 7.15 (d, J=2.4 Hz, 1H), 7.19-7.26 (m, 1H), 7.75 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 242 (M+H)+.

Sources & evidence

ORD record
ord-3f1673dd1d4f4a3b8f7577d1847b4d0c
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

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