HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3,4-Difluorophenyl)-3-(pyrazin-2-yl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,4-Difluorophenylacetylene | HCID 13878454 | — |
| Reactant | N-Hydroxypyrazine-2-carbimidoyl chloride | HCID 136395910 | — |
| Product | 5-(3,4-Difluorophenyl)-3-(pyrazin-2-yl)isoxazole | HCID 44545683 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and 4-ethynyl-1,2-difluorobenzene (Apollo, 69 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.38-7.54 (m, 2H), 7.74-7.84 (m, 1H), 7.90 (ddd, J=11.1, 7.5, 2.0 Hz, 1H), 8.70 (d, J=2.4 Hz, 1H), 8.76 (dd, J=2.4, 1.6 Hz, 1H), 9.29 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-9b36bfde5093462481d5a679766c2cdd |
| Source note | uspto-grants-2013_02 |