反应详情

21.2 g (207 mmol) of manganese dioxide are added to 10.6 g (34.5 mmol) of (3-butoxy-4-iodophenyl)methanol in 70 mL of dichloromethane. The reaction mixture is stirred at room temperature for 2 days. The reaction medium is filtered through Celite. The filtrate is evaporated and the oil obtained (9.45 g) is purified by chromatography on silica gel eluted with a 90/10 heptane/ethyl acetate mixture. 7.7 g (73%) of 3-butoxy-4-iodobenzaldehyde are obtained in the form of a yellow oil.

1. filtrationThe reaction medium is filtered through Celite
2. customThe filtrate is evaporated
3. customthe oil obtained (9.45 g)
4. customis purified by chromatography on silica gel
5. washeluted with a 90/10 heptane/ethyl acetate mixture