(3-Butoxy-4-iodophenyl)methanol → 3-Butoxy-4-iodobenzaldehyde

Participants

Reaction Steps

21.2 g (207 mmol) of manganese dioxide are added to 10.6 g (34.5 mmol) of (3-butoxy-4-iodophenyl)methanol in 70 mL of dichloromethane. The reaction mixture is stirred at room temperature for 2 days. The reaction medium is filtered through Celite. The filtrate is evaporated and the oil obtained (9.45 g) is purified by chromatography on silica gel eluted with a 90/10 heptane/ethyl acetate mixture. 7.7 g (73%) of 3-butoxy-4-iodobenzaldehyde are obtained in the form of a yellow oil.

Provenance & Evidence