反应详情

A solution of 50 g (0.45 mol) of pentyl isocyanate in 50 mL of dichloromethane is added to a mixture of 82 g (0.45 mol) of (3-bromophenyl)methylamine in 250 mL of dichloromethane in the presence of 20 mL (0.14 mol) of triethylamine. The reaction medium is heated at reflux for 3 days and then hydrolyzed in 200 mL of 1 N hydrochloric acid solution and extracted with ethyl acetate. The organic phases are combined, washed with water, with saturated sodium chloride solution and evaporated. 123 g (93%) of 1-(3-bromophenyl)-1-methyl-3-pentylurea are obtained.

1. temperatureThe reaction medium is heated
2. temperatureat reflux for 3 days
3. extractionhydrolyzed in 200 mL of 1 N hydrochloric acid solution and extracted with ethyl acetate
4. washwashed with water, with saturated sodium chloride solution
5. customevaporated