反应详情

温度

120 °C

To a 4 mL vial equipped with a septum cap and stir bar was added N-(5-methyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide (21 mg, 0.1 mmol), copper(I) trifluoromethanesulfonate benzene complex (10 mg, 0.02 mmol), 5-chloro-1,10-phenanthroline (8.5 mg, 0.04 mmol) and cesium carbonate (38.9 mg, 0.12 mmol). The mixture was placed under a nitrogen atmosphere. Iodobenzene (0.12 mmol) in 1-methyl-2-pyrrolidinone (1.0 mL) was added to the mixture. The reaction mixture was heated at 120° C. for overnight. A solution of concentrated ammonium hydroxide/water (1:2, 1 mL) was added and the mixture was filtered and solvent removed under reduced pressure. The residue was purified by reverse phase HPLC (C8, gradient 10-100% acetonitrile/water/0.1% trifluoroacetic acid).

1. customTo a 4 mL vial equipped with a septum
2. customcap
3. filtrationthe mixture was filtered
4. customsolvent removed under reduced pressure
5. customThe residue was purified by reverse phase HPLC (C8, gradient 10-100% acetonitrile/water/0.1% trifluoroacetic acid)