反应详情

To a Parr flask was added 20% Pd(OH)2 on carbon (23.2 mg) followed by addition of methanol (22 mL). To this suspension was added a solution N-[2-{1-[benzyl(methyl)amino]-propyl}-5-(trifluoromethyl)benzyl]-N-[3,5-bis(trifluoromethyl)-benzyl]-2-methyl-2H-tetrazol-5-amine (298.7 mg, 0.463 mmoles) in methanol. The reaction mixture was stirred under hydrogen (pressure =14.7 psi) at room temperature for 9 hours. The reaction mixture was filtered through Celite, washed with methanol, concentrated under vacuo to give 279.8 mg (100%) of the title compound as yellow oil. MS (ES+) Calc: 608.5, Found: 609.1 (M+1).

1. filtrationThe reaction mixture was filtered through Celite
2. washwashed with methanol
3. concentrationconcentrated under vacuo