Trifluoroacetic acid → 1231755-16-0

HRID 390772Notes

Reaction equation

HRID 390772 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC(=O)[NH:14][CH2:15][C:16](=[O:23])[NH:17][CH2:18][C:19]([F:22])([F:21])[F:20])(C)(C)C>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[F:20][C:19]([F:22])([F:21])[CH2:18][NH:17][C:16]([CH2:15][NH3+:14])=[O:23]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71623152HCID 71623152, compound

Product 1

HCID 1317302671231755-16-0

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoracetic acid (23.4 ml) is added dropwise to a solution of [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-carbamic acid ter-butyl ester (3.89 g) in dichloromethane (75 ml). After 18 hours at room temperature, the reaction mixture is concentrated in vacuo. The crude oil is purified by crystallization in diethylether to yield (2,2,2-trifluoro-ethylcarbamoyl)methyl-ammonium trifluoroacetate (4.12 g) as a white solid.

Workup

  1. concentrationthe reaction mixture is concentrated in vacuo
  2. customThe crude oil is purified by crystallization in diethylether

Sources & evidence

ORD record
ord-45e05ee86ff04d29bb6da30040973fb3
Source dataset
uspto-grants-2013_02
Patent number
US08383659B2

Reaction notes

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