Hydrochloric Acid → Ractopamine hydrochloride

HRID 390784Notes

Reaction equation

HRID 390784 reaction equation
[CH3:1][CH:2]([NH:12][CH2:13][CH:14]([OH:22])[C:15]1[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[ClH:23]>O>[CH3:1][CH:2]([NH:12][CH2:13][CH:14]([OH:22])[C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[ClH:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56052Ractopamine

Product 1

HCID 14010333Ractopamine hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Samples of ractopamine can be isolated and purified from conveniently available commercial sources. One kilogram of commercially available Paylean® (Elanco) was stirred overnight with 15 L of water. The mass was filtrated, and the filtrate (11.5 L) was evaporated under reduced pressure to a small volume (ca. 1-2 L). Aqueous potassium carbonate was added to raise pH to ca. 10, and the solution was extracted twice with equal volumes of ethyl acetate. The ethyl acetate extracts were combined, evaporated under reduced pressure to ca. 0.5 L, and an equal volume of hexanes added. After standing overnight, crystals of ractopamine free base (6.83 g) were filtrated. This material was crystallized again from ethyl acetate/hexanes to give pure ractopamine free base (6.01 g). HPLC showed 98.5% purity. A sample of ractopamine free base (120 mg) was stirred with 10 ml of deionized water cooled in an ice-water bath, and 2 M aqueous hydrochloric acid (2 ml) was added slowly. After stirring to dissolve the material, the solution was filtered and lyophilised to give ractopamine hydrochloride (125 mg). The mp was 128-135° C., lit (Merck Index) mp 124-129° C. 1H NMR was consistent. HPLC showed 98.0% chemical purity.

Workup

  1. temperaturecooled in an ice-water bath
  2. dissolutionto dissolve the material
  3. filtrationthe solution was filtered

Sources & evidence

ORD record
ord-849072bce3bd4285bbd11ac9976b133b
Source dataset
uspto-grants-2013_02
Patent number
US08383685B2

Reaction notes

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