Hydrochloric Acid → HCID 66654616, compound

HRID 390974Notes

Reaction equation

HRID 390974 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([CH3:17])(=[O:16])=[O:15])[C@H:10]([CH3:18])[CH2:9]1)=O)(C)(C)C.[ClH:19]>ClCCl.C(OCC)C>[ClH:19].[CH3:17][S:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]1[CH3:18])(=[O:15])=[O:16]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58007208tert-Butyl (3R)-3-Methyl-4-(methylsulfonyl)piperazine-1-carboxylate

Product 1

HCID 66654616HCID 66654616, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of (R)-4-methanesulfonyl-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (924 mg) in dichloromethane (20 mL) at 0° C. was added dropwise HCl (6.65 mL of a 2 M solution in diethyl ether). The reaction mixture was stirred at room temperature for 2 h. The precipitate formed was then collected by filtration and dried to afford (R)-1-methanesulfonyl-2-methyl-piperazine hydrochloride salt as a white solid (520 mg, 73%).

Workup

  1. customThe precipitate formed
  2. filtrationwas then collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-2cac2c2694a54b978dac29cd8a5b0768
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

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