Hydrochloric Acid → 1032757-93-9

HRID 390979Notes

Reaction equation

HRID 390979 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CO.ClCCl.C(OCC)C>[ClH:22].[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[S:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:16])=[O:15]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 17255579tert-Butyl 4-(thiophene-2-sulfonyl)piperazine-1-carboxylate

Product 1

HCID 467434531032757-93-9

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(2-Thiophenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (759 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (11.4 ml) was added and the reaction mixture was stirred at room temperature overnight, then cooled in ice bath, the resulted precipitate was filtered, washed with ether to yield 4-(2-thiophenesulfonyl)-piperazine hydrochloride salt (529 mg).

Workup

  1. temperaturecooled in ice bath
  2. filtrationthe resulted precipitate was filtered
  3. washwashed with ether

Sources & evidence

ORD record
ord-9b0aa01a386e49b6b194060d6771ce59
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

Loading…