Hydrochloric Acid → 1032757-97-3

HRID 390981Notes

Reaction equation

HRID 390981 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[S:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)(=[O:15])=[O:16]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 46180303HCID 46180303, compound

Product 1

HCID 242507551032757-97-3

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(2-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (891 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (12.9 ml) was added and the reaction mixture was stirred at room temperature overnight, then cooled in ice bath, the resulted precipitate was filtered, washed with ether to yield 4-(2-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (600 mg).

Workup

  1. temperaturecooled in ice bath
  2. filtrationthe resulted precipitate was filtered
  3. washwashed with ether

Sources & evidence

ORD record
ord-37d14f265bac4b0497dadab7f9b90fa8
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

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