Hydrochloric Acid → Piperazine, 1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-, hydrochloride (1:1)

Participants

Reaction Steps

4-(1-Methylimidazole-4-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (730 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (11 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(1-methylimidazole-4-sulfonyl)-piperazine hydrochloride salt (704 mg).

Provenance & Evidence