Hydrochloric Acid → Piperazine, 1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-, hydrochloride (1:1)

HRID 390989Notes

Reaction equation

HRID 390989 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[N:18]=[CH:19][N:20]([CH3:22])[CH:21]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>CO.ClCCl.C(OCC)C>[ClH:23].[CH3:22][N:20]1[CH:21]=[C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:15])=[O:16])[N:18]=[CH:19]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 58561856HCID 58561856, compound

Product 1

HCID 66934082Piperazine, 1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-, hydrochloride (1:1)

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(1-Methylimidazole-4-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (730 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (11 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(1-methylimidazole-4-sulfonyl)-piperazine hydrochloride salt (704 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-27af5b22d9364865a94ee20b22edb91d
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

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