Hydrochloric Acid → 1-(4-Fluorobenzene-1-sulfonyl)piperazine--hydrogen chloride (1/1)

HRID 390991Notes

Reaction equation

HRID 390991 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 4634543HCID 4634543, compound

Product 1

HCID 173683141-(4-Fluorobenzene-1-sulfonyl)piperazine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(4-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (937 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (13.6 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(4-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (819 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-bba8de4c52164eee843962ab9e57b083
Source dataset
uspto-grants-2013_02
Patent number
US08383620B2

Reaction notes

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