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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 391073생성일: 2026년 10월 25일

3-Nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidin-2-yl)-3-nitropyridin-2-amine

https://huagongshe.com/reaction/391073

반응식

참여 물질

역할이름HCID투입량
반응물3-Nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 46738009—
반응물2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidineHCID 56833946—
생성물5-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidin-2-yl)-3-nitropyridin-2-amineHCID 5823406816.8%

반응 단계

4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[2,3-d]pyrimidin-4-yl)morpholine (100 mg, 0.2 mmol) was reacted with 3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (0.24 g, 0.9 mmol) according to General Procedure Suzuki to afford 360 (18 mg) following reverse phase HPLC purification. MS (Q1) 535 (M)+

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08383620B2
출처 데이터셋uspto-grants-2013_02
ORD IDord-2c9886e45a754aa882bc646dfda8bd42
출처 메모uspto-grants-2013_02