huagongshe.com
HRID391169

反应详情

EQUATION

反应方程式

HRID 391169 的结构方程式

REACTANTS

反应物

3
结构：O=C(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl
HCID8303

1,1,1,3,3,3-Hexachloro-2-propanone

C3Cl6O

结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：CC(C)(C)C(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)C(=O)[C@H]5C[C@H]5[C@H]4[C@@H]3[C@@H](O)[C@H]3O[C@]32C1
HCID13075958

5beta,6beta-Epoxy-7beta-hydroxy-15beta,16beta-methylene-3beta-pivaloyloxy-5 beta-androstan-17-one

C25H36O5

PRODUCTS

生成物

1
结构：CC(C)(C)C(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)C(=O)[C@H]5C[C@H]5[C@H]4[C@@H]3[C@H](Cl)[C@H]3O[C@]32C1
HCID13075960

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

CONDITIONS

反应条件

温度
1 °C

PROCEDURE

实验过程

A solution of 5,6β-epoxy-7β-hydroxy-15β,16β-methylen-3β-pivaloyloxy-5β-androstan-17-one (1.66 g, 0.004 mol) in dichloromethane (8 mL) is treated with hexachloroacetone (2 mL, 0.013 mol) and cooled to 0-2° C. Triphenylphosphine (1.53 g, 0.0044 mol) in dichloromethane (4 mL) is added dropwise and the mixture is stirred for one hour at 3-4° C., then for an additional hour at 10-15° C.

WORKUP

后处理

  1. customat 10-15° C.