反应详情

To a solution of 2-(5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoyl)-3-dimethylaminoacrylic acid ethyl ester prepared in Step XII in toluene was added (S)-2-amino-3-methylbutan-1-ol (3.96 g) with stirring at room temperature. After stirring for 30 min, 1N hydrochloric acid (60 ml) was added, and the mixture was further stirred for 1 hr. The organic layer was separated, and washed successively with water (60 ml), 5% sodium hydrogencarbonate (60 ml) and water (60 ml). The organic layer was concentrated under reduced pressure. N,N-dimethylformamide (40 ml) was added to the residue, and the mixture was concentrated again under reduced pressure. The residue was dissolved in N,N-dimethylformamide (60 ml) to give a solution of 2-(5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoyl)-3-((S)-1-hydroxymethyl-2-methylpropylamino)acrylic acid ethyl ester in N,N-dimethylformamide. This was identified as the title compound by HPLC.

1. stirringAfter stirring for 30 min
2. stirringthe mixture was further stirred for 1 hr
3. customThe organic layer was separated
4. washwashed successively with water (60 ml), 5% sodium hydrogencarbonate (60 ml) and water (60 ml)
5. concentrationThe organic layer was concentrated under reduced pressure
6. additionN,N-dimethylformamide (40 ml) was added to the residue
7. concentrationthe mixture was concentrated again under reduced pressure
8. dissolutionThe residue was dissolved in N,N-dimethylformamide (60 ml)