4-Chloro-6-(chloromethyl)pyrimidin-2-amine → 2-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

HRID 3915Notes

Reaction equation

HRID 3915 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1>C(OCC)C.Cl>[ClH:8].[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1

Participants

4

Reactant 1

HCID 201534884-Chloro-6-(chloromethyl)pyrimidin-2-amine

Product 1

HCID 201535002-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

3.56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine was dissolved in 53 parts of dry diethyl ether and dry hydrogen chloride was bubbled through the solution, with stirring, until no further solid precipitated the solid was filtered, washed with ether and dried in vacuo. Recrystallisation from acetone gave 2-amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride m.p. 145°-150° C. (decomposition).

Workup

  1. customwas bubbled through the solution
  2. customprecipitated the solid
  3. filtrationwas filtered
  4. washwashed with ether
  5. customdried in vacuo
  6. customRecrystallisation from acetone

Sources & evidence

ORD record
ord-58de8242ae774164a8154c623f6db4b7
Source dataset
uspto-grants-1988_02
Patent number
US04723006

Reaction notes

Loading…