反应详情

To a solution of (S)-6-amino-N-[methyl(oxo)phenyl-λ6-sulfanylidene]-5-[(trimethylsilyl)ethynyl]nicotinamide (308 mg, 0.83 mmol) in 20 mL THF/methanol (1:1 ratio) at 0° C. was added K2CO3 (344 mg, 2.5 mmol) added. After 7 minutes the solution was decanted from the solids and partitioned between EtOAc and H2O. The EtOAc layer was washed with brine, dried with anhydrous Na2SO4 and rotary evaporated. The brown oil was purified by chromatography (silica gel, CHCl3/EtOAc) to give the title compound as a white solid (193 mg, 78%).

1. additionadded
2. customAfter 7 minutes the solution was decanted from the solids
3. custompartitioned between EtOAc and H2O
4. washThe EtOAc layer was washed with brine
5. dry with materialdried with anhydrous Na2SO4 and rotary evaporated
6. customThe brown oil was purified by chromatography (silica gel, CHCl3/EtOAc)