Methyl iodide → HCID 178498104, compound

HRID 391615Notes

Reaction equation

HRID 391615 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:7][CH:6]=1)=[O:4].[CH3:16][I:17]>C1COCC1.CO>[I-:17].[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([N+:11]2[CH:15]=[CH:14][N:13]([CH3:16])[CH:12]=2)=[CH:9][CH:10]=1)=[O:4]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 2766374Methyl 4-(1H-imidazol-1-yl)benzoate

Product 1

HCID 178498104HCID 178498104, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

A solution of 1-(4′-methoxycarbonylphenyl)imidazole (153 g, 0.76 mol) in 1:1 THF/methanol (600 ml) is admixed with methyl iodide (196 ml, 2.27 mol) and stirred at room temperature under argon for 16 h. After concentration of the solution, the precipitated product is filtered off and washed with THF. Yield: 59%.

Workup

  1. filtrationAfter concentration of the solution, the precipitated product is filtered off
  2. washwashed with THF

Sources & evidence

ORD record
ord-21e057ffbeb843aba9ac696796e5e7ab
Source dataset
uspto-grants-2013_02
Patent number
US08384068B2

Reaction notes

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