HCID 178470292, compound → HCID 178489571, compound

HRID 391658Notes

Reaction equation

HRID 391658 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]2[N:17]=[C:16]3[C:12]([NH:13][C:14](=[O:26])[N:15]3[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])=[C:11]([C:27]([O:29]CC)=O)[N:10]=2)[CH2:4][CH2:3]1.[NH2:32]C1C(C(OCC)=O)=NC(N[C@H]2CC[C@H](O)CC2)=NC=1NC1C=CC=CC=1OC>ClCCl>[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]2[N:17]=[C:16]3[C:12]([NH:13][C:14](=[O:26])[N:15]3[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])=[C:11]([C:27]([NH2:32])=[O:29])[N:10]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 178470292HCID 178470292, compoundHCID 178470294HCID 178470294, compound

Product 1

HCID 178489571HCID 178489571, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethyl 2-(trans-4-hydroxycyclohexylamino)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate and the imidazole ester. Ethyl 5-amino-2-(trans-4-hydroxy-cyclohexylamino)-6-(2-methoxyphenylamino)pyrimidine-4-carboxylate (0.240 g, 0.598 mmol) and 1,1′-1,1′-carbonyldiimidazole (0.968 g, 5.98 mmol) in dichloromethane (20 mL) were reacted according to general procedure F. A mixture of the title compound and the imidazole ester were formed and were taken on without further purification. MS (ESI) m/z 399 [M+1]+ (title compound), 522 [M+1]+ (imidazole urea).

Sources & evidence

ORD record
ord-2df8fc267a40472c8f1cbe2d40b90b55
Source dataset
uspto-grants-2013_02
Patent number
US08383634B2

Reaction notes

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