HCID 178470292, compound → HCID 178489571, compound

Participants

Reaction Steps

Ethyl 2-(trans-4-hydroxycyclohexylamino)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate and the imidazole ester. Ethyl 5-amino-2-(trans-4-hydroxy-cyclohexylamino)-6-(2-methoxyphenylamino)pyrimidine-4-carboxylate (0.240 g, 0.598 mmol) and 1,1′-1,1′-carbonyldiimidazole (0.968 g, 5.98 mmol) in dichloromethane (20 mL) were reacted according to general procedure F. A mixture of the title compound and the imidazole ester were formed and were taken on without further purification. MS (ESI) m/z 399 [M+1]+ (title compound), 522 [M+1]+ (imidazole urea).

Provenance & Evidence