HCID 57474682, compound → HCID 57474687, compound

HRID 391663Notes

Reaction equation

HRID 391663 reaction equation
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[N:22]=[C:21]4[C:17]([NH:18][C:19](=[O:31])[N:20]4[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[O:29][CH3:30])=[C:16]([C:32]([O:34]CC)=O)[N:15]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[NH2:37]C1C(C(OCC)=O)=NC(NC2C=CC(CO)=CC=2)=NC=1NC1C=CC=CC=1OC>ClCCl>[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[N:22]=[C:21]4[C:17]([NH:18][C:19](=[O:31])[N:20]4[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[O:29][CH3:30])=[C:16]([C:32]([NH2:37])=[O:34])[N:15]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 57474682HCID 57474682, compoundHCID 57474684HCID 57474684, compound

Product 1

HCID 57474687HCID 57474687, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethyl 2-(4-((1H-imidazol-1-yl)methyl)phenylamino)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate. Ethyl 5-amino-2-(4-(hydroxymethyl)phenylamino)-6-(2-methoxyphenylamino)pyrimidine-4-carboxylate (0.180 g, 0.440 mmol) and 1,1′-1,1′-carbonyldiimidazole (0.713 g, 4.44 mmol) in dichloromethane (20 mL) were reacted according to General Procedure F and purified using Biotage silica gel chromatography (10% methanol in ethyl acetate) to afford the title compound (0.700 g, >100%). MS (ESI) m/z 486.5 [M+1]+.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-54b92abe1025495b9315d775b851652f
Source dataset
uspto-grants-2013_02
Patent number
US08383634B2

Reaction notes

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