HCID 57474682, compound → HCID 57474687, compound

Participants

Reaction Steps

Ethyl 2-(4-((1H-imidazol-1-yl)methyl)phenylamino)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate. Ethyl 5-amino-2-(4-(hydroxymethyl)phenylamino)-6-(2-methoxyphenylamino)pyrimidine-4-carboxylate (0.180 g, 0.440 mmol) and 1,1′-1,1′-carbonyldiimidazole (0.713 g, 4.44 mmol) in dichloromethane (20 mL) were reacted according to General Procedure F and purified using Biotage silica gel chromatography (10% methanol in ethyl acetate) to afford the title compound (0.700 g, >100%). MS (ESI) m/z 486.5 [M+1]+.

Provenance & Evidence